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KMID : 0870420030070010102
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Korean Journal of Hepato-Biliary-Pancreatic Surgery
2003 Volume.7 No. 1 p.102 ~ p.107
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Cyclooxygenase-2 Expression in Intrahepatic Cholangiocarcinoma
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Hahn Koo-Yong
Hong Seong-Woo
Kang Yun-Kyung
Heo Tae-Kil
Chang Yeo-Goo
Paik In-Wook
Lee Hyuck-Sang
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Abstract
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Background/Aims: Cyclooxygenase (COX)-2 levels are elevated in several types of human cancer tissues. COX-2 is not constitutively expressed by most normal tissues, but it is rapidly induced by certain inflammatory cytokines, tumor promoters, growth factors and oncogenes. Inflammation is important risk factor for intrahepatic cholangiocarcinoma. Therefore, this study was aimed to evaluate the role of COX-2 in intrahepatic cholangiocarcinoma development.
Methods: 18 intrahepatic cholangiocarcinoma patients was conducted in this study. COX-2 expression was investigated by immunohistochemical staining in resected liver specimen that involved 47 hyperplasia, 30 low-grade dysplasia, 38 high-grade dysplasia and 18 cancer. The relationship of clinicopathological factor and COX-2 expression of cancer was evaluated.
Results: COX-2 expression was not observed in normal bile duct epithelium. COX-2 expression in high-grade dysplasia was higher than in low-grade dysplasia. COX-2 expression in cancer wash higher than in hyperplasia, low-grade and high grade dysplasia. There was no significant correlation between clinicopathological factors and COX-2 expression in cancer.
Conclusion: These findings suggest that COX-2 may play a role in the early and late carcinogensis of intrahepatic cholangiocarcinoma.
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KEYWORD
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Intrahepatic cholangiocarcinoma, Cyclooxygenase-2, Carcinogenesis
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